A single antenatal course of betamethasone adversely affects glucose regulation in adulthood and the next generation in childhood
نویسندگان
چکیده
Methods A cohort of 52 adults (aged 35.7 years, 46% men, 23 born after steroid treatment) and their term-born children (n=61, aged 8.0 years, 52% boys, 49% from a parent born after steroid treatment), was recruited in Auckland. Insulin sensitivity and secretion were assessed using hyperglycaemic clamps in adults, and HOMA-IR in children. Other assessments included DXA-derived body composition, lipid profile, adipokines, and 24-hour ambulatory blood pressure monitoring.
منابع مشابه
Does antenatal Betamethasone improve neonatal outcome in late preterm births?
Background and Objective: Preterm birth is a public health problem and late preterm birth (deliveries between 34-36 weeks of gestation) accounts for 75% of all preterm births. Antenatal Betamethasone can reduce the severity of respiratory distress in preterm infants and its effect is accepted in 24-34 weeks of gestation. Our goal was to determine the neonatal outcomes of Betamethasone prescr...
متن کاملDoes antenatal Betamethasone improve neonatal outcome in late preterm births?
Introduction: Preterm birth is a public health problem and late preterm birth (deliveries between 34-36 weeks of gestation) accounts for 75% of all preterm births. Antenatal Betamethasone can reduce the severity of respiratory distress in preterm infants and its effect is accepted in 24-34 weeks of gestation. Our goal was to determine the neonatal outcomes of Betamethasone prescription in late ...
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Administration of antenatal corticosteroids to pregnant women with imminent delivery of a newborn at 24 to 34 weeks of gestation represents one of the most important advances in perinatal medicine in the past 25 years1,2. A single course of antenatal steroid has been associated with a decrease in acute neonatal systemic morbidity and mortality after preterm birth reducing the risk of respirator...
متن کاملAntenatal Dexamethasone For Women at Risk af Preterm Birth and Intraventricular Haemorrhage: What is the Truth?
Administration of antenatal corticosteroids to pregnant women with imminent delivery of a newborn at 24 to 34 weeks of gestation represents one of the most important advances in perinatal medicine in the past 25 years1,2. A single course of antenatal steroid has been associated with a decrease in acute neonatal systemic morbidity and mortality after preterm birth reducing the risk of respirator...
متن کاملAntenatal exposure to betamethasone: psychological functioning and health related quality of life 31 years after inclusion in randomised controlled trial.
OBJECTIVES To determine if antenatal exposure to betamethasone for the prevention of neonatal respiratory distress syndrome alters psychological functioning and health related quality of life in adulthood. DESIGN Follow-up of the first and largest double blind, placebo controlled, randomised trial of a single course of antenatal betamethasone for the prevention of neonatal respiratory distres...
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ورودعنوان ژورنال:
دوره 2015 شماره
صفحات -
تاریخ انتشار 2015